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目的:观察强心胶囊对充血性心力衰竭大鼠心肌细胞凋亡的影响。方法:用Wistar大鼠腹腔注射阿霉素造模,分中药预防组、中药治疗组和西药对照组治疗,原位末端标记法检测心肌细胞凋亡,免疫组化检测Fas/Bcl-2心内表达水平。结果:强心胶囊明显抑制充血性心力衰竭大鼠心肌细胞凋亡,抑制Fas蛋白表达,提高Bcl-2表达。结论:强心胶囊能明显抑制心肌细胞凋亡和调节Fas/Bcl-2,这可能是其延缓充血性心力衰竭进展的作用机理之一。
Objective: To observe the effect of Qiangxin capsule on myocardial cell apoptosis in congestive heart failure rats. METHODS: Wistar rats were intraperitoneally injected with adriamycin and divided into Chinese medicine group, traditional Chinese medicine group and western medicine control group. Cardiomyocyte apoptosis was detected by in situ end labeling. Fas/Bcl-2 expression was detected by immunohistochemistry. The expression level. RESULTS: Qiangxin Capsule significantly inhibited cardiomyocyte apoptosis in rats with congestive heart failure, inhibited Fas protein expression and increased Bcl-2 expression. Conclusion: Qiangxin Capsule can obviously inhibit cardiomyocyte apoptosis and regulate Fas/Bcl-2, which may be one of the mechanisms that delay the progression of congestive heart failure.