论文部分内容阅读
N-甲基-D-天冬氨酸(NMDA)受体是兴奋性谷氨酸受体的一种亚型,是学习记忆中的关键物质。在癫痫发作后可观察到NMDA受体的过度激活,引起细胞膜内外离子失衡,激活神经毒性信号转导途径,导致神经元损伤或死亡,从而造成一系列神经元功能的障碍,最终导致认知功能受损。通过对癫痫NMDA受体作用机制的研究,为防治癫痫认知障碍提供了新方向。
N-methyl-D-aspartate (NMDA) receptor is a subtype of excitatory glutamate receptors, a key substance in learning and memory. After seizures can be observed over-activation of NMDA receptors, causing intracellular ion imbalance within and outside the cell, activating the neurotoxic signaling pathway, leading to neuronal damage or death, resulting in a series of neuronal dysfunction, eventually leading to cognitive function Damaged. Through the study of the mechanism of epilepsy NMDA receptor, it provides a new direction for the prevention and treatment of epileptic cognitive disorders.