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目的:探讨微生态制剂对于老年危重患者抗菌药相关性腹泻的预防作用。方法:选择2004年12月～2008年12月应用抗菌药治疗的住院老年危重患者218例,根据抗感染治疗同时是否应用微生态制剂(金双歧)随机分为预防组(110例)和对照组(108例),观察两组抗菌药相关性腹泻(AAD)发生情况。结果:预防组AAD发生13例,发生率11.82%;对照组AAD发生36例,发生率33.33%,预防组AAD发生率明显低于对照组(P<0.01)。预防组AAD发生时间(7.65±2.80)d,病程(3.17±2.85)d,对照组AAD发生时间(5.50±2.47)d,病程(5.86±2.88)d。两组比较差异有统计学意义。结论:微生态制剂(金双歧)有助于防止老年危重患者AAD发生。
Objective: To explore the preventive effect of probiotics on antimicrobial-drug-associated diarrhea in critically ill elderly patients. Methods: A total of 218 hospitalized elderly critically ill patients treated with antibacterials from December 2004 to December 2008 were randomly divided into prevention group (110 cases) and control group according to whether antimicrobial therapy (Jinshuangqi) 108 cases), observed two groups of antibacterial drug-related diarrhea (AAD) occurred. Results: AAD occurred in 13 cases (11.82%) in the prevention group and 36 cases (33.33%) in the control group. The incidence of AAD in the prevention group was significantly lower than that in the control group (P <0.01). The duration of AAD in the prevention group (7.65 ± 2.80) d, duration of disease (3.17 ± 2.85) days and control group (5.50 ± 2.47) d, duration of disease (5.86 ± 2.88) d. The difference between the two groups was statistically significant. Conclusion: The probiotics (Jinshuangqi) can help prevent AAD in elderly critically ill patients.