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目的探讨老年骨肉瘤患者的临床特点及预后。方法收集2010至2013年我院收治的30例老年人(≥60岁)骨肉瘤病例进行回顾性分析,运用SPSS 13.0软件进行统计学分析,预后因素采用χ~2检验;根据相关随访资料统计生存率。结果 30例中,男19例,女11例,年龄60~86岁,平均70岁。28例平均随访25个月,2例失访,随访率为93.3%。28例获随访者均经手术治疗,其中单纯手术治疗13例,术后辅助放疗6例,术后辅助放化疗9例。28例获随访者中,1年生存率约67.8%;3年生存率为35.7%。单纯手术切除组与手术联合放化疗组,生存差异有统计学意义(P<0.01)。血清碱性磷酸酶(AKP)升高者较正常者预后差,差异有统计学意义(P<0.05)。结论对于老年性骨肉瘤患者手术联合放化疗对改善预后有益。AKP可作为预测患者预后的指标之一。
Objective To investigate the clinical characteristics and prognosis of elderly patients with osteosarcoma. Methods A total of 30 elderly patients (≥60 years) with osteosarcoma admitted to our hospital from 2010 to 2013 were retrospectively analyzed. SPSS 13.0 software was used for statistical analysis. The prognostic factors were analyzed by χ ~ 2 test. The survival rate was calculated according to the relevant follow-up data rate. Results 30 cases, 19 males and 11 females, aged 60 to 86 years, mean 70 years. Twenty-eight patients were followed up for an average of 25 months. Two patients were lost to follow-up. The follow-up rate was 93.3%. 28 cases were followed up by surgical treatment, including simple surgery in 13 cases, postoperative adjuvant radiotherapy in 6 cases, adjuvant radiotherapy and chemotherapy in 9 cases. Of the 28 patients who were followed up, the 1-year survival rate was 67.8% and the 3-year survival rate was 35.7%. There was significant difference in the survival between the simple surgical resection group and the operation combined with radiotherapy and chemotherapy group (P <0.01). Serum alkaline phosphatase (AKP) increased compared with the normal prognosis was poor, the difference was statistically significant (P <0.05). Conclusion For patients with senile osteosarcoma surgery combined with radiotherapy and chemotherapy to improve prognosis. AKP can be used as an index to predict the prognosis of patients.