一、前言脂质体(Liposomes)是将药物包封于类脂质双分子层形成的薄膜中间所成的超微型球状体。在脂质体理论研究的基础上,1971年英国Ryman等人开始将脂质体作为药物载体加以研究,近年来脂质体广泛的用作抗癌药物的载体,它具备一些独特的作用特点:如使药物具有药理活性的专一性,选择性地杀伤癌细胞或抑制癌细胞的繁殖;降低药物对正常细胞的毒性,减少剂量,减轻变态或免疫反应;增加药物对淋巴系统的指 I. Introduction Liposomes are ultramicrospheres formed by encapsulating drugs in the middle of the lipid-bilayer membrane. Based on the theoretical study of liposomes, Ryman et al. Began to study liposomes as drug carriers in 1971. In recent years, liposomes have been widely used as carriers of anticancer drugs and have some unique features. Such as the pharmacological activity of drugs with specificity, selective killing of cancer cells or inhibit the proliferation of cancer cells; reduce the toxicity of drugs on normal cells, reduce the dose, reduce the abnormal or immune response; increase the drug on the lymphatic system fingers