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目的 观察肿瘤侵袭诱导基因蛋白在正常胎儿组织和不同类型癌组织中的表达。方法 采用肿瘤侵袭诱导基因蛋白制备的单克隆抗体,进行免疫组化染色。结果 正常胎儿组织中腺上皮、平滑肌等细胞有不同程度表达;几乎所有癌细胞均显示表达增强,特别是低分化及侵袭性强的癌细胞呈高表达。结论 肿瘤侵袭诱导蛋白作为一种与细胞信号传导有关的细胞骨架系统调节蛋白,其表达增强与细胞增生活跃及肿瘤侵袭性有关。
Objective To observe the expression of tumor invasion-inducing gene proteins in normal fetal tissues and different types of cancer tissues. Methods Monoclonal antibody prepared by tumor invasion-induced gene protein was used for immunohistochemical staining. Results In normal fetal tissues, glandular epithelium, smooth muscle and other cells were expressed in different degrees; almost all cancer cells showed enhanced expression, especially in poorly differentiated and aggressive cancer cells. Conclusion Tumor invasion-inducing protein is a cytoskeletal system-regulatory protein involved in cell signal transduction. Its increased expression is associated with active cell proliferation and tumor invasiveness.