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许多报道已经表明,阿片类物质的作用(如镇痛,摄食等)可以被八肽胆囊收缩素(CCK-8)所对抗,但其机制不明。CCK-8的抗阿片作用可以发生在受体水平,也有可能发生在受体后第二信使水平。在外周组织,特别是在胰腺的外分泌细胞,CCK-8能刺激肌醇磷脂转化产生肌醇三磷酸(InsP_3)和甘油二酯(DAG);这两种第二信使可以使细胞内的Ca~(2+)储存释放并激活蛋白激酶C(PKC)。虽然外周与中枢的CCK-8在受体机制和生理功能方面有很
Many reports have shown that opioid effects (such as analgesia, feeding, etc.) can be antagonized by the octapeptide cholecystokinin (CCK-8), but its mechanism is unknown. The anti-opioid effect of CCK-8 can occur at the receptor level and also at the second messenger level after the receptor. In peripheral tissues, especially in pancreatic exocrine cells, CCK-8 stimulates the conversion of inositol phospholipid to produce inositol triphosphate (InsP 3) and diglyceride (DAG). These two second messengers can make intracellular Ca ~ (2+) stores and activates protein kinase C (PKC). Although peripheral and central CCK-8 receptor mechanisms and physiological functions are very good