论文部分内容阅读
目的探讨正常血压人群血压变化与钠钾反应性的关系。方法 2004-04-10对陕西眉县正常血压成人(年龄>16岁)339位进行低盐饮食7d,高盐饮食7d的慢性盐负荷实验,之后进行高盐+补钾干预7d,以平均动脉压(MAP)升高≥10%为盐敏感组(n=80),<10%为盐不敏感组(n=259);以补钾后MAP下降10%为标准分为补钾MAP下降≥10%组(n=61),补钾MAP下降<10%组(n=278)。于2009年对该队列人群进行随访调查。结果①完成随访共275人,总随访率为81.2%,其中盐敏感组随访率为83.8%,盐不敏感组为80.3%,补钾MAP下降≥10%组为83.6%,补钾血压下降<10%组为80.6%。②5年后,与盐不敏感组比较,盐敏感组血压变化幅度大,无论收缩压还是舒张压均明显升高,高血压患病率也显著升高。③与补钾MAP下降<10%组比较,补钾MAP下降≥10%组的血压变化幅度较小。结论盐敏感性是高血压发病的重要危险因素,血压对钾敏感是高血压的一个保护因素。
Objective To investigate the relationship between changes of blood pressure and sodium and potassium in normotensive subjects. Methods A total of 339 healthy adults (aged> 16 years) with normal blood pressure in Meixian County of Shaanxi Province underwent chronic salt loading for 7 days and high salt diet for 7 days. After high salt and potassium supplement for 7 days, mean arterial pressure Increased pressure (MAP) ≥10% for salt-sensitive group (n = 80), <10% salt-sensitive group (n = 259); MAP decreased by 10% 10% group (n = 61) and potassium supplement <10% (n = 278). The cohort was followed up in 2009. Results ① A total of 275 follow-up visits were performed with a total follow-up rate of 81.2%. The follow-up rate was 83.8% in salt-sensitive group, 80.3% in salt-sensitive group, 83.6% The 10% group was 80.6%. After 5 years, compared with the salt-insensitive group, the change of the blood pressure in the salt-sensitive group was large, both systolic and diastolic pressures were significantly increased, and the prevalence of hypertension was also significantly increased. ③Compared with <10% potassium supplement, the change of blood pressure in MAP decreased more than 10%. Conclusion Salt sensitivity is an important risk factor for hypertension. Sensitivity of blood pressure to potassium is a protective factor of hypertension.