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目的 探讨增殖细胞核抗原 (PCNA )表达与肝细胞癌临床病理参数及预后的关系。方法 采用SABC法检测 42例肝细胞癌及癌旁组织中PCNA的表达。结果 PCNA在肝细胞癌中的阳性表达率显著高于癌旁组织 (P <0 .0 5 ) ,且PCNA的表达与Edmondson Steiner分级呈正相关 (P <0 .0 1)。在浸润型 (IHCC)有转移组中PCNA分值均显著高于膨胀型 (EHCC)无转移组(P <0 .0 1)。肿瘤直径≤ 3cm者PCNA分值也明显低于 >3cm者 (P <0 .0 5 )。PCNA高增殖组患者生存期明显低于低增殖组 (P<0 .0 5 )。结论 PCNA反映癌细胞的增殖程度 ,可作为判断肝细胞癌恶性程度及其预后的指标。
Objective To investigate the relationship between the expression of proliferating cell nuclear antigen (PCNA) and clinicopathological parameters and prognosis of hepatocellular carcinoma. Methods SABC method was used to detect the expression of PCNA in 42 cases of hepatocellular carcinoma and its adjacent tissues. Results The positive expression rate of PCNA in hepatocellular carcinoma was significantly higher than that in paracancerous tissues (P <0.05), and the expression of PCNA was positively correlated with Edmondson Steiner grade (P <0.01). The PCNA score in IHCC metastasis group was significantly higher than that in EHCC non-metastasis group (P <0.01). The PCNA score of tumor diameter ≤ 3 cm was also significantly lower than> 3 cm (P <0.05). The survival of PCNA hyperproliferative group was significantly lower than that of low proliferative group (P <0.05). Conclusion PCNA reflects the degree of proliferation of cancer cells, which can be used as an indicator of malignancy and prognosis of hepatocellular carcinoma.