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目的探索组织因子(TF)在人肝细胞肝癌(HCC)血管生成中的作用。方法用免疫组织化学EnVisionTM法检测50例HCC及相应的癌旁肝组织标本中TF和CD34的表达。结果HCC中TF表达与患者静脉浸润、肝内外转移、无或包膜不完整有关,MVD与静脉浸润、肝内外转移、肝硬化有关(P<0.05);HCC中TF阳性组与阴性组的MVD值之间差异有统计学意义(F=5.487,P=0.023);Cox模型提示TF的表达是影响HCC患者总生存率的独立因素之一。结论TF可能参与HCC微血管生成,TF对评估HCC患者预后有参考价值。
Objective To explore the role of tissue factor (TF) in angiogenesis of human hepatocellular carcinoma (HCC). Methods Immunohistochemistry EnVisionTM method was used to detect the expression of TF and CD34 in 50 cases of HCC and corresponding paracancerous liver tissue specimens. Results The expression of TF in HCC was correlated with venous invasion, extrahepatic metastasis, incomplete or incomplete capsule, MVD was associated with venous invasion, extrahepatic metastasis and cirrhosis (P <0.05). MVD in TF positive group and negative group in HCC The difference between the two groups was statistically significant (F = 5.487, P = 0.023). Cox model suggested that the expression of TF was an independent factor affecting the overall survival of HCC patients. Conclusions TF may be involved in the angiogenesis of HCC. TF may provide a reference value for evaluating the prognosis of patients with HCC.