目的　探讨口服米索前列醇混悬液用于足月妊娠胎膜早破产妇引产的有效性和安全性。方法　 12 0例孕足月胎膜早破的初产妇 ,分为两组。A组 6 0例口服米索混悬液 (2 0 0 μg/ 2 0 0 ml) ,每 2 h1次 ,初起每次 2 0 ml,连续 3次后若无规律宫缩出现 ,第 4次起改为每次 40 ml,若出现有效宫缩即停药 ,否则直至服完 2 0 0 ml。B组 6 0例静滴催产素作对照。结果　 A组引产成功率 96 .7% ,高于 B组的 85 .0 % (P<0 .0 5 )。A组从首次用药至临产及阴道分娩的平均时间较B组明显缩短 (P<0 .0 5 )。A组剖宫产率较 B组显著降低 (P<0 .0 1)。两组产后 2 h出血量及羊水污染、胎儿窘迫、新生儿窒息的发生率间差异均无显著性。口服米索混悬液用于足月妊娠胎膜早破产妇引产是一种安全、有效、方便的方法 ,且效果优于催产素 Objective To investigate the efficacy and safety of oral misoprostol suspension for induction of labor in term pregnant women with premature rupture of membranes. Methods 120 cases of premature rupture of membranes premature rupture of primipara, divided into two groups. A group of 60 cases of oral misoprostol (200 microg / 200 ml), every 2 h 1 times, the first 20 ml each time for three consecutive if no regular uterine contractions appear, the first 4 Changed to 40 ml each time, if there is effective contractions that are discontinued, or until served 200 ml. Group B 60 intravenous infusion of oxytocin as a control. Results The success rate of induction of labor in group A was 96.7%, higher than 85.0% in group B (P <0.05). The average time from the first administration to labor and vaginal delivery in group A was significantly shorter than that in group B (P <0.05). Cesarean section rate in group A was significantly lower than that in group B (P <0.01). Two groups of postpartum 2 h bleeding and amniotic fluid contamination, fetal distress, the incidence of neonatal asphyxia no significant difference. Oral Misoprostol for Pregnancy Premature rupture of membranes Maternal induction of labor is a safe, effective and convenient method, and the effect is better than oxytocin