论文部分内容阅读
目的探讨广东汉族人群KIR-HLA信号系统表达规律。方法对79例广东汉族正常人行KIR、HLA分型,根据KIR-HLA间识别规律,分析各KIR-HLA受体配体对的频率。结果KIR2DL2/3-HLA-CwAsn80(65.8%)是主要的抑制性KIR-HLA受体配体对,其次是KIR3DL1-HLA-BBw4(62.6%),KIR3DL1-HLA-A11(54.2%),和KIR2DL1-HLA-CwLys80(25.4%)。表达KIR2DL1,KIR2DL2/3或KIR3DL1而不表达相应HLA配体的频率分别是63.3%、1.3%、31.6%。KIR2DS1-HLA-CwLys80,KIR2DS2-HLA-CwAsn80,KIR3DS1-HLA-BBw4的频率分别是2.5%、26.6%、16.5%。结论KIR-HLA信号系统在广东汉族人群有较高的多样性。
Objective To investigate the expression of KIR-HLA signaling in Guangdong Han population. Methods KIR and HLA typing were performed in 79 Han normal subjects in Guangdong. According to the pattern of KIR-HLA recognition, the frequency of each KIR-HLA receptor ligand pair was analyzed. Results KIR2DL2 / 3-HLA-CwAsn80 (65.8%) was the major inhibitory KIR-HLA receptor ligand pair followed by KIR3DL1-HLA-BBw4 (62.6%), KIR3DL1-HLA- A11 (54.2%), and KIR2DL1 -HLA-CwLys80 (25.4%). The frequencies of expressing KIR2DL1, KIR2DL2 / 3 or KIR3DL1 but not corresponding HLA ligands were 63.3%, 1.3%, 31.6%, respectively. The frequencies of KIR2DS1-HLA-CwLys80, KIR2DS2-HLA-CwAsn80 and KIR3DS1-HLA-BBw4 were 2.5%, 26.6% and 16.5%, respectively. Conclusion The KIR-HLA signaling system has a high diversity in Guangdong Han population.