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目的:观察不同剂量干扰素α1b雾化治疗小儿毛细支气管炎的疗效及安全性。方法:随机选择在我院儿科住院治疗的毛细支气管炎患儿共240例,分为不使用重组人干扰素α1b组(对照组)、重组人干扰素α1b低剂量组(低剂量组)、重组人干扰素α1b高剂量组(高剂量组)各80例,比较三组患儿治疗有效率、临床症状改善情况及不良反应。结果:低剂量组总有效率93.75%,高剂量组总有效率95.00%,对照组总有效率81.25%,低剂量组、高剂量组与对照组比较差异均有统计学意义(P<0.05),但低剂量组与高剂量组疗效比较差异无统计学意义(P>0.05);低剂量组、高剂量组患儿症状、体征消失时间及住院时间均明显短于对照组(P<0.05),但低剂量组与高剂量组症状、体征消失时间及住院时间比较差异无统计学意义(P>0.05)。所有雾化干扰素的患儿均未发现明显不良反应。结论:雾化吸入干扰素α1b治疗小儿毛细支气管炎疗效显著,未发现明显不良反应,说明低剂量干扰素α1b雾化治疗更具有临床推广价值。
Objective: To observe the efficacy and safety of different doses of interferon α1b atomization in children with bronchiolitis. Methods: A total of 240 children with bronchiolitis who were hospitalized in our hospital for pediatric bronchial asthma were randomly divided into two groups: the control group, the low-dose recombinant interferon alb-1b group, the low-dose recombinant interferon- Interferon α1b high dose group (high dose group) of 80 cases, the treatment of children in three groups were compared, the improvement of clinical symptoms and adverse reactions. Results: The total effective rate was 93.75% in low dose group, 95.00% in high dose group and 81.25% in control group. There was significant difference between low dose group and high dose group (P <0.05) , But there was no significant difference between the low-dose group and the high-dose group (P> 0.05). The symptoms and signs disappeared and the length of hospital stay in the low-dose and high-dose groups were significantly shorter than those in the control group (P <0.05) , But there was no significant difference in symptoms, signs disappear time and hospital stay between low-dose group and high-dose group (P> 0.05). No adverse reactions were found in all children with nebulized interferon. Conclusion: Inhaled interferon α1b is effective in treating children with bronchiolitis, and no obvious adverse reactions have been found. It indicates that the low dose interferon α1b atomization therapy has more clinical value.