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应用免疫组化ＳＰ方法研究８６例甲状腺癌、１５例甲状腺腺瘤和２５例肿瘤旁正常甲状腺组织中增殖细胞核抗原（ＰＣ－ＮＡ）的表达及意义。结果显示：ＰＣＮＡ计数在癌组织中明显高于腺瘤及正常组织（Ｐ＜０．０１）；ＰＣＮＡ表达与甲状腺癌的病理类型、ＴＮＭ分期和术后生存期密切相关（Ｐ＜０．０１）。表明ＰＣＮＡ表达程度可以反映甲状腺癌的细胞增殖活性，检测该蛋白对评估甲状腺癌的生物学行为和预后有一定参考价值。
Immunohistochemical SP method was used to study the expression and significance of proliferating cell nuclear antigen (PC-NA) in 86 cases of thyroid cancer, 15 cases of thyroid adenoma and 25 cases of normal thyroid tissue around the tumor. The results showed that PCNA counts were significantly higher in cancer tissues than in adenomas and normal tissues (P<0.01); PCNA expression was closely related to the pathological type, TNM stage, and postoperative survival of thyroid cancer (P<0.01). . It indicates that the degree of PCNA expression can reflect the cell proliferation activity of thyroid cancer. The detection of this protein has certain reference value for evaluating the biological behavior and prognosis of thyroid cancer.