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目的 为了观察运动锻炼对弹性蛋白酶诱导肺气肿的影响。 方法 ４４ 只ＳＤ 大鼠，雌雄各半，先随机分为２ 组肺气肿组和对照组，肺气肿组一次性经气管内滴注猪胰弹性蛋白酶８００ Ｅｕ／ｋｇ（２００Ｅｎ／ｍ ｌ０．９％ ＮａＣｌ），对照组滴注等体积０． ９％ ＮａＣｌ液。注酶后４ 周再将２ 组随机分为运动组和非运动组，即： 正常对照组（ＮＣ），正常运动组（ＮＥ），肺气肿对照组（ＥＣ） 和肺气肿运动组（ＥＥ），然后进行为期１２ 周的运动平板锻炼。 结果 与ＮＣ组比较，ＥＣ 和ＥＥ组肺灌注体积与体重比增大（Ｐ＜ ０．００１，Ｐ＜０．０５），排除与灌注体积比变小（Ｐ＜ ０．００１），单位面积的肺泡个数减少（Ｐ＜ ０．００１），平均肺泡面积增加（Ｐ＜ ０．００５）， 但上述检测参数在ＮＣ与ＮＥ 组和ＥＣ与ＥＥ 组间未见明显差异。 结论 在我们所选定的运动强度下，运动锻炼对正常及肺气肿大鼠肺弹性和病理形态变化无明显影响，可能不会加重肺气肿进程。
Objective To observe the effect of exercise on elastase-induced emphysema. Methods Forty-four SD rats were randomly divided into two groups: emphysema group and control group. The emphysema group was intraperitoneally instilled with porcine pancreatic elastase 800 Eu / kg (200En / ml10) 9% NaCl), the control group drip volume 0. 9% NaCl solution. After 4 weeks of enzyme instillation, the two groups were randomly divided into exercise group and non-exercise group: normal control group (NC), normal exercise group (NE), emphysema control group (EC) and emphysema exercise group EE) followed by 12-week exercise treadmill exercise. Results Compared with NC group, the volume and weight ratio of lung perfusion in EC and EE groups increased (P <0.001, P <0.05), and the volume of exclusion and perfusion decreased (P <0.001) The number of alveoli decreased (P <0.001) and the average alveolar area increased (P <0.005). However, there was no significant difference between the NC and NE groups and the EC and EE groups. Conclusions Exercise exercise has no effect on the changes of lung elasticity and pathology in normal and emphysematous rats, and may not aggravate the course of emphysema under the exercise intensity we selected.