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对抗叶酸制剂和喹淋类抗疟药的作用机制已研究了数十年,近年来的进展应有助于新药的研制以与越来越难制服的疟原虫作斗争。原虫对抗叶酸制剂抗性的分子水平描述已相当明确,归因于药物靶酶的结构改变。但与原虫逃避喹啉类抗疟药有关的因子仍有待阐明。本综述讨论这些药物的作用方式及原虫用以对抗化疗的方法。
The mechanism of action against folic acid preparations and quinoline antimalarials has been studied for decades and advances in recent years should facilitate the development of new drugs to combat the more and more unmanageable malaria parasite. The molecular level description of protozoal resistance to folate preparations has been fairly well defined due to the structural changes of the drug target enzymes. However, the factors associated with protozoa evading quinoline antimalarial drugs remain to be elucidated. This review discusses the mode of action of these drugs and the methods used by protozoans to combat chemotherapy.