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目的:分析和研究急性非静脉曲张性上消化道出血应用十灰散治疗的临床疗效。方法:纳入2013年7月—2015年1月急性非静脉曲张性上消化道出血患者100例,按照随机数字表法随机分为中医组与西医组,每组各有患者50例。所有患者行常规对症支持和干预,西医组患者辅以奥美拉唑进行止血;中医组患者辅以十灰散进行止血,对比两组止血效果、72 h再出血率、用药不良作用发生率、平均止血时间、平均住院时间、治疗前后症状评分的变化。结果:两组患者止血效果相似,差异经χ2检验显示无统计学意义(P>0.05)。中医组72 h再出血率、用药不良作用发生率明显低于西医组,差异经χ2检验有统计学意义(P<0.05)。两组患者治疗前症状评分相似,差异经t检验显示无统计学意义(P>0.05)。中医组患者治疗后症状评分明显低于西医组,且平均止血时间、平均住院时间明显短于西医组,差异经t检验显示有统计学意义(P<0.05)。结论:急性非静脉曲张性上消化道出血应用十灰散治疗的临床疗效确切,可在安全用药的基础上有效止血,促进患者胃痞、胃痛、纳差等症状的改善,缩短止血和住院时间,改善患者预后,值得推广。
Objective: To analyze and study the clinical efficacy of Shihuisan in the treatment of acute non-variceal upper gastrointestinal bleeding. Methods: A total of 100 patients with acute non-variceal upper gastrointestinal bleeding from July 2013 to January 2015 were randomly divided into TCM group and WM group according to random number table. Each group included 50 patients. All patients underwent routine symptomatic support and intervention. Patients in Western medicine group were treated with omeprazole to stop bleeding. Patients in Chinese medicine group were treated with Decoction for hemostasis. The effect of hemostasis, recurrence after 72 h, incidence of adverse drug effects, Mean hemostasis time, average length of stay, changes in symptoms before and after treatment. Results: The hemostatic effects of two groups were similar, the difference was not statistically significant by χ2 test (P> 0.05). The recurrence rate of 72 h in Chinese medicine group was significantly lower than that in Western medicine group (P <0.05). The difference was significant by χ2 test (P <0.05). Two groups of patients before treatment symptom scores were similar, the difference was not statistically significant by t test (P> 0.05). The symptom score of TCM group was significantly lower than that of Western medicine group, and the mean hemostasis time and average length of stay were significantly shorter than that of Western medicine group. The difference was statistically significant by t test (P <0.05). Conclusion: Acute non-variceal upper gastrointestinal bleeding Shiyan San treatment of clinical efficacy of the exact, safe medication can be based on the effective hemostasis to promote the patient’s stomach pik, stomach pain, anorexia and other symptoms to improve and shorten the bleeding and hospital stay , Improve patient’s prognosis, it is worth promoting.