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目的：探讨高渗氯化钠 醋酸钠溶液对低血容量性休克改善作用的机制。方法：成年ＳＤ大鼠随机分为３ 组：７．５％ ＮａＣｌ治疗组（ＨＳ组）、５％ ＮａＣｌ＋ ３．５％ ＮａＡｃ治疗组（ＨＳＡ 组）和０．９％ ＮａＣｌ对照组（ＮＳ组）。用高倍显微电视放大技术在体观察低血容量性休克时脊斜肌细静脉白细胞附壁数，用细胞液流室离体观察白细胞 内皮细胞粘附率的变化。结果：休克后各组细静脉白细胞附壁数显著增加，ＨＳＡ 显著减少细静脉白细胞附壁数，ＨＳ可短暂减少白细胞附壁数。在不同的壁切应力作用下，ＨＳＡ 组白细胞 内皮细胞粘附率显著低于ＨＳ组和ＮＳ组，ＨＳ组白细胞与内皮细胞的粘附率与ＮＳ组比较无显著差别。结论：ＨＳＡ 有改善低血容量性休克大鼠白细胞粘附特性的作用
Objective: To investigate the mechanism of hypertonic sodium chloride sodium acetate solution to improve hypovolemic shock. Methods: Adult SD rats were randomly divided into three groups: 7.5% NaCl treatment group (HS group), 5% NaCl + 3.5% NaAc treatment group (HSA group) and 0.9% NaCl control group . Observation of the number of leukocytes in the spina bifida muscle during the observation of hypovolemic shock in high magnification micro-television magnification technique, and the changes of the adhesion rate of leukocyte endothelium cells in vitro were observed by flow cytometry. Results: After the shock, the number of leucocytes in each group significantly increased, HSA significantly reduced the numbers of leucocytes in the vein and HS decreased the numbers of leukocytes temporarily. Under different wall shear stress, the adhesion rate of leukocyte endothelial cells in HSA group was significantly lower than that in HS group and NS group. The adhesion rate of leukocytes and endothelial cells in HS group was not significantly different from that in NS group. Conclusion: HSA can improve leukocyte adhesion in hypovolemic shock rats