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作者对15例头颈部不能手术切除的有大块肿瘤和/或大块颈部转移的患者〈T_(3-4)或N_3〉,进行每日两次放射治疗的临床研究。如果这些患者进行每日一次放疗,其结果至多就是有轻度消退或暂时的生长抑制,亦即局部未能得到控制。全组患者均经病理证实为上呼吸道及消化道鳞癌,以前未作过任何放射治疗或并用化疗。病人每日二次治疗,每周5天,共7～8周,二次治疗的间隔为四小时。每次肿瘤量为1.1 Gy,每日肿瘤量为2.2 Gy。而每日用一次治疗时,肿瘤量为1.75～2 Gy。每次均给予双侧野治疗。45 Gy后保护脊髓,60 Gy后进一步缩野。肿瘤总剂量为75 Gy,而每日一次治疗方案则为70 Gy。每周检查纪录肿瘤
The authors conducted a clinical study of twice-daily radiotherapy for 15 patients with large tumors and/or large neck metastases (T_(3-4) or N_3) that could not be surgically resected on the head and neck. If these patients were treated with radiation once a day, the result was at best mild subsidence or temporary inhibition of growth, ie local failure to control. All patients were pathologically confirmed as squamous cell carcinomas of the upper respiratory tract and digestive tract. No radiation therapy or chemotherapy was used before. The patient was treated twice daily for five days a week for a total of 7 to 8 weeks and the secondary treatment interval was four hours. The tumor volume was 1.1 Gy each time and the daily tumor volume was 2.2 Gy. When treated once a day, the tumor volume was 1.75-2 Gy. Bilateral treatment was given each time. The spinal cord was protected after 45 Gy and further contracted after 60 Gy. The total tumor dose was 75 Gy, while the once-a-day treatment program was 70 Gy. Weekly examination of recorded tumors