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目的 研究小鼠急性中度骨髓型放射损伤期间红细胞免疫粘附功能的变化及中药养阴抗毒散的放射防护作用 .方法 以 6 Gy X射线照射后小鼠作为动物模型 ,给予中药养阴抗毒散灌胃 ,应用酵母菌红细胞花环试验测定红细胞免疫粘附功能 .结果 和正常组 (RBC- C3b R花环率 15 .4%±4.3% ,RBC- IC花环率 14.8%± 3.1% )相比 ,照射对照组小鼠RBC- C3b R花环率从第 12日 (8.0± 2 .6 ) %开始下降 (P<0 .0 1) ,实验结束时 (10 .1± 3.2 ) %仍未恢复正常 ,RBC- IC花环率在照后第 4日 (19.9± 2 .2 ) %和 8d(19.5± 3.1) %升高(P<0 .0 1) ,随后逐步下降至正常 .照射中药组小鼠 RBC- C3bR花环率仅在第 12日 (10 .5± 3.0 ) %下降 (P<0 .0 1) ,RBC-IC花环率仅在第 4日 (18.5± 3.0 ) %升高 (P<0 .0 5 ) ,照射中药组 RBC- C3b R花环率在第 4,12 ,2 0 ,2 8日均高于照射对照组(P<0 .0 5 ) .结论 6 Gy X线照射可造成小鼠红细胞免疫功能低下 ,中药养阴抗毒散对此有一定的预防和治疗作用
Objective To investigate the changes of red blood cell immune adherence function and the radioprotective effect of Yangyin antitoxic powder in mice with acute moderate bone marrow-type radiation injury.Methods The mice were treated with 6 Gy X-rays as an animal model and the anti-Yang Poisoned by gavage, yeast red blood cell garland test was used to determine the red blood cell immune adhesion function. Results were compared with the normal group (RBC-C3b R rosette rate was 15.4% ± 4.3%, RBC-IC rosette rate was 14.8% ± 3.1%) The rosette rate of RBC-C3b R in the irradiated control mice decreased from the (8.0±2.6)% on the 12th day (P<0.01), but remained unchanged at the end of the experiment (10·1±3.2%). The rosette rate of RBC-IC rose at 4th day (19.9±2.2%) and 8d (19.5±3.1)% (P<0.01), then gradually decreased to normal. The rosette rate of RBC-C3bR only decreased on the 12th day (10. 5± 3.0) % (P<0. 01), and the RBC-IC rosette rate only increased on the 4th day (18.5± 3.0)% (P<0. .0 5) The rate of rosette RBC-C3b R rose in the Chinese Herbal Medicine group was higher than that in the irradiated control group on the 4th, 12th, 20th, and 28th day (P<0.05). Conclusion The 6 Gy X-ray irradiation can cause small Low immune function of mouse red blood cells, nourishing Yin Anti-drugs have a certain degree of prevention and treatment