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这是WHO赞助的多中心多国家LNG阴道环(IVR)临床试验的一部分,只限于英国两个城市的150例(伦敦99例,曼切斯特51例)共1417.5个妇女月的试验报告。参与研究的是自愿育龄健康妇女,月经规则,平均年龄27.6岁(18～35岁),受试前3个月内未用过长效激素避孕药,1个月内未用过口服避孕药(OC)。阴道环由WHO供给,医用级硅橡胶制成直径55.6mm横断面9.5mm,内装含左旋18甲基炔诺酮(LNG)5mg的合成橡胶蕊,体外LNG释放率为20±3μg/24h,可持续用90天。
This is part of a multi-center, multinational multinational LNG vaginal ring (IVR) trial sponsored by the WHO and is limited to 1417.5 women’s monthly trials in 150 of the UK’s two cities (99 in London and 51 in Manchester). Participants in the study are voluntary women of childbearing age, menstrual rules, the average age of 27.6 years (18 to 35 years), 3 months before the test did not use long-acting hormonal contraceptives, not used within 1 month of oral contraceptives OC). Vaginal ring is supplied by WHO. Medical grade silicone rubber is made of synthetic rubber core with a diameter of 55.6mm and a cross-section of 9.5mm. It contains 5mg of levonorgestrel (LNG). The in vitro LNG release rate is 20 ± 3μg / 24h Continue for 90 days.