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目的探讨甲胎蛋白(AFP)、甲胎蛋白异质体-L3(AFP-L3)、高尔基体蛋白73(GP73)在原发性肝癌的诊断价值。方法采用酶联免疫吸附法和电化学发光法检测68例原发性肝癌、49例良性肝病及68例健康体检者血清中AFP、AFP-L3、GP73的含量,并进行比较。结果原发性肝癌患者组血清AFP、AFP-L3、GP73含量明显高于良性肝病及健康对照组(P<0.05和P<0.01);三者联合检测的特异度和敏感度优于单独检测,所得数据有统计学意义。结论 AFP、AFP-L3、GP73联合检测可明显提高原发性肝癌诊断的敏感性和特异性。
Objective To investigate the diagnostic value of AFP, AFP-L3 and GP73 in primary hepatocellular carcinoma. Methods The serum levels of AFP, AFP-L3 and GP73 in 68 cases of primary hepatocellular carcinoma, 49 cases of benign liver disease and 68 cases of healthy subjects were detected by enzyme-linked immunosorbent assay and electrochemiluminescence. Results The serum levels of AFP, AFP-L3 and GP73 in patients with primary liver cancer were significantly higher than those in patients with benign liver disease and healthy controls (P <0.05 and P <0.01). The specificity and sensitivity of the combined tests were better than those of patients with primary hepatocellular carcinoma alone, The data obtained were statistically significant. Conclusion Combined detection of AFP, AFP-L3 and GP73 can significantly improve the sensitivity and specificity of diagnosis of primary liver cancer.