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应用本室建立的小鼠SRS淋巴细胞腹水瘤细胞,给昆明种小鼠皮下注射2×10~6个/只,可以100％发生实体瘤。皮下瘤结呈进行性生长,至第18天时,瘤结平均重量可达3.13克/只,不会自发消退。肿瘤小鼠平均的存活时间为23.6天(11～32天)。小鼠的性别和鼠龄不影响SRS实体瘤的移植发生率,但是15～20克体重的昆明种小鼠的肿瘤生长较快而重。应用SRS瘤细胞5×10~6个/只,接种CJR、615、A、SWI、BALB/C和C57BL近交系小鼠,也都全部发生实体瘤。对昆明种SRS实体瘤小鼠的外周血液进行动态观察,至第18天时,白细胞总数平均可达41,200/mm~3,但幼稚细胞为2％,提示仅引
Using the mouse SRS lymphocyte ascites tumor cells established in this laboratory, subcutaneous injection of 2×10~6 mice into the Kunming mice can produce 100% solid tumors. The subcutaneous neoplasia showed progressive growth. On the 18th day, the average weight of the neoplasm reached 3.13 g/body and did not spontaneously subside. The average survival time of tumor mice was 23.6 days (11 to 32 days). The gender and age of the mice did not affect the incidence of transplants of solid tumors of SRS, but tumors of 15 to 20 grams of Kunming mice grew faster and heavier. Using SRS tumor cells 5 × 10 ~ 6 / only, inoculated with CJR, 615, A, SWI, BALB / C and C57BL inbred strains of mice, all solid tumors. The peripheral blood of Kunming mice with SRS solid tumors was dynamically observed. On the 18th day, the total number of white blood cells was 41.200/mm~3 on average, but the immature cells were 2%.