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由上海医药工业研究院、湖南益阳市油脂化工厂、湖南艮沙制药厂协作研制成功的半合成脂肪酸酯栓剂基质及制剂复方氨哮素栓、阿司匹林栓的技术鉴定会于1979年6月26日至29日在长沙市召开。湖南省卫生局、省医药管理局共同主持了这次会议。有关单位的69名代表参加了鉴定会。会议听取了利用资源丰富的野生植物山鸡椒的果实——山苍子的核仁油为原料,制成半合成脂肪酸酯栓剂基质的研究报告及复方氯哮素栓、阿司匹林拴的临床疗效观察。代表们经过讨论,通过了技术鉴定书。山鸡椒[Litseacubeba(Louv.)Pers.]主产于我国江南各地。其果实山苍子的皮油中含有芳香油,主要成分为柠檬醛,每年有大量出口。蒸去芳香油后的核仁,尚有40%的脂肪油,经压榨后得山苍子的核仁油。它的组成类似椰子油,主要成分为月桂酸甘油酯。将山苍子脂肪酸减压分溜得到的十二碳脂肪酸部分进行结晶和精制,可得到月桂酸,再通过酯化反应即制成山苍子脂肪酸酯。产品质量稳定,符合栓剂基质要求,生产工艺
By the Shanghai Pharmaceutical Industry Research Institute, Yiyang City, Hunan oleochemical factory, Hunan Gusha Pharmaceutical Co., Ltd. successfully developed semi-synthetic fatty acid ester suppository matrix and preparation of compound ammonia Astragalus suppository, aspirin bolt technology identification will be June 26, 1979 Day to 29 held in Changsha City. Hunan Provincial Health Bureau, Provincial Medical Administration co-chaired the meeting. 69 representatives of relevant units participated in the appraisal meeting. The meeting heard the use of resource-rich wild plant bell pepper fruit - Litsea cubeba kernel oil as raw material, made of semi-synthetic fatty acid ester suppository matrix research reports and compound chloramphenicol suppository, aspirin tethering clinical efficacy Observed. After discussion, the deputies passed the technical appraisal book. Hill pepper [Litseacubeba (Louv.) Pers.] Mainly produced in all parts of southern China. The fruit of Litsea cubeba oil contains aromatic oil, the main component of citral, a large number of exports each year. Steamed aromatic oil kernels, there are still 40% of fat oil, crushed litsea cubeba kernel oil. Its composition is similar to coconut oil, the main component of glycerol laurate. The litsea cubeba fatty acid fractional distillation of the twelve carbon fatty acid part of the crystallization and purification, available lauric acid, and then through the esterification reaction made litsea cubeba fatty acid ester. Product quality and stability, in line with suppository matrix requirements, production technology