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目的 :考察中脑边缘多巴胺能系统在小剂量吗啡点燃诱导吗啡觅药行为重建中的作用。方法 :将小剂量儿茶酚胺能神经毒素 6 羟多巴胺微量注射到双侧伏核 (1g·L-1)或腹侧背盖区 (5g·L-1) ,观察其对已消退的吗啡条件性位置偏爱之点燃重建的作用。结果 :6 羟多巴胺微量注射到腹侧背盖区选择性地损毁多巴胺能神经元的胞体 ,或注射到伏核以损毁多巴胺能纤维的末梢 ,均可完全消除小剂量吗啡 (0 .2 5mg·kg-1,s.c.)的点燃效应。结论 :中脑边缘多巴胺能系统功能的完整性是药物点燃导致条件位置偏爱重建的必要条件。
OBJECTIVE: To investigate the role of the midbrain edge dopaminergic system in morphine-induced drug-induced behavioral remodeling induced by low-dose morphine. Methods: A small dose of catecholaminergic neurotoxin 6 hydroxydopamine was injected into the nucleus accumbens (1g · L-1) or ventral tegmental area (5g · L-1) Preference ignites the role of reconstruction. RESULTS: Microinjection of 6-hydroxydopamine into the ventral tegmental area selectively destroyed the soma of dopaminergic neurons or injected into the nucleus accumbens to damage the terminals of dopaminergic fibers, which could completely eliminate low-dose morphine (0.25mg · kg-1, sc) ignition effect. CONCLUSIONS: The functional integrity of the midbrain edge dopaminergic system is a prerequisite for drug-induced repositioning of the conditioned place preference.