论文部分内容阅读
为探讨低剂量辐射对高剂量辐射诱发小鼠胸腺淋巴瘤抑制作用的免疫学机制，采用４次１．７５ＧｙＸ射线全身照射Ｃ５７ＢＬ／６Ｊ小鼠诱发胸腺淋巴瘤模型，检测不同辐射剂量照后１个月小鼠脾脏ＮＫ细胞毒活性及其ＩＬ－２和γ－ＩＦＮ分泌活性，腹腔巨噬细胞吞噬功能及其ＴＮＦ－α分泌活性。结果显示，每次１．７５Ｇｙ照射前１２ｈ接受７５ｍＧｙ照射小鼠，上述免疫功能均比单纯１．７５Ｇｙ照射组增强，且接近假照射组小鼠。提示低剂量辐射抑制高剂量辐射诱发胸腺淋巴瘤可能与低剂量辐射诱导的适应性反应，减轻高剂量辐射对机体免疫功能的损伤有关。
To investigate the immunological mechanism of low dose radiation on the inhibition of thymoma in mice induced by high dose radiation, thymus lymphoma model was induced by 4 times 1.75Gy X-ray in C57BL / 6J mice and 1 NK cell cytotoxic activity, IL-2 and γ-IFN secretion activity, phagocytic function and TNF-α secretion activity of peritoneal macrophages in the mouse spleen. The results showed that 75 mGy irradiated mice were irradiated with 1.75 Gy irradiation 12h before each irradiation. The above immune function was enhanced compared with the 1.75Gy irradiation group and close to the mice in the sham irradiation group. It is suggested that low dose radiation can inhibit the adaptive response induced by high dose radiation to thymine lymphoma induced by low dose radiation and reduce the damage of high dose radiation to immune function.