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持续、明显的低氧血症是COPD肺动高压(PH)的主要原因。即使肺动脉高压并不很高(肺动脉压平均2.67～4.67kPa),也可能是其预后不良的标志。人们观察到,这类患者在睡眠时换气紊乱加剧(特别表现为通气不足,及通气/灌注失调加重),有时出现较为严重而突然减饱和高峰,导致肺动脉压突然升高。这类患者预后仍以其日间低氧血水平起着决定性作用。(王骏摘陈肖嘉校)
Sustained, significant hypoxemia is the main cause of pulmonary hypertension (PH) in COPD. Even if the pulmonary hypertension is not very high (average pulmonary artery pressure 2.67 ~ 4.67kPa), may also be a sign of poor prognosis. It has been observed that these patients experience increased ventilatory disturbances during sleep (especially with hypoventilation and increased ventilatory / perfusion imbalance) and sometimes severe and sudden desaturation peaks, resulting in a sudden increase in pulmonary pressure. The prognosis of these patients still plays a decisive role in their hypoxemia during the day. (Wang Chun Chen Shaojiao school pick)