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目的:通过对25例骨髓增生异常综合征(MDS)患者的血象及骨髓象的分析,以提高诊断MDS的水平。方法:对25例西宁地区MDS住院患者血象、骨髓象的形态学及病态造血进行分析。结果:25例患者,难治性贫血(RA)3例(占12%),难治性贫血伴铁粒幼细胞增多(RAS)1例,难治性血细胞减少伴多系发育异常(RCMD)8例(占32%),难治性贫血伴原始细胞增多-I型(RAEB-I)8例(占32%),难治性贫血伴原始细胞增多II型(RAEB-II)5例(占20%)。结论:外周血细胞减少、病态造血以及原始细胞数量增多是MDS的主要特点,但有时血象及骨髓象表现不典型,缺乏特异性,由于MDS的这些特点,使其诊断尤显困难,特别是形态学改变不明显时,需要与一些疾病进行鉴别。
Objective: To improve the diagnosis of MDS by analyzing the blood and bone marrow of 25 patients with myelodysplastic syndrome (MDS). Methods: 25 cases of MDS hospitalized in Xining, blood morphology, bone marrow morphology and pathological hematopoietic analysis. Results: Twenty - five patients had refractory anemia (RA) in 3 patients (12%), refractory anemia with increased neutrophil count (RAS) in 1, refractory cytopenia with multiple lineage dysplasia (RCMD) 8 cases (32%), refractory anemia with RAEB-I in 8 cases (32%), refractory anemia with rheumatoid arthritis (RAEB-II) in 5 cases Accounting for 20%). CONCLUSIONS: Peripheral blood cells, pathological hematopoiesis, and increased number of primary cells are the main features of MDS. However, blood and bone marrow manifestations are sometimes not typical and lack specificity. Due to these characteristics of MDS, diagnosis is particularly difficult, especially morphological Change is not obvious, you need to identify some diseases.