【摘 要】
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Although millions of patients have clinically recovered from COVID-19,little is known about the immune status of lymphocytes in these individuals.In this study,the peripheral blood mononuclear cells of a clinically recovered(CR)cohort were comparatively a
【机 构】
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Shanghai Public Health Clinical Center,Fudan University,Shanghai 201508,China;Joint Laboratory of In
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Although millions of patients have clinically recovered from COVID-19,little is known about the immune status of lymphocytes in these individuals.In this study,the peripheral blood mononuclear cells of a clinically recovered(CR)cohort were comparatively analyzed with those of an age-and sex-matched healthy donor cohort.We found that CD8+T cells in the CR cohort had higher numbers of effector T cells and effector memory T cells but lower Tc1(IFN-y+),Tc2(IL-4+),and Tc17(IL-17A+)cell frequencies.The CD4+T cells of the CR cohort were decreased in frequency,especially the central memory T cell subset.Moreover,CD4+T cells in the CR cohort showed lower programmed cell death protein 1(PD-1)expression and had lower frequencies of Th1(IFN-y+),Th2(IL-4+),Th17(IL-17A+),and circulating follicular helper T(CXCR5+PD-1+)cells.Accordingly,the proportion of isotype-switched memory B cells(lgM-CD20hi)among B cells in the CR cohort showed a significantly lower proportion,although the level of the activation marker CD71 was elevated.For CD3-HLA-DR-lymphocytes in the CR cohort,in addition to lower levels of IFN-y,granzyme B and T-bet,the correlation between T-bet and IFN-y was not observed.Additionally,by taking into account the number of days after discharge,all the phenotypes associated with reduced function did not show a tendency toward recovery within 4-11 weeks.The remarkable phenotypic alterations in lymphocytes in the CR cohort suggest that severe acute respiratory syndrome coronavirus 2 infection profoundly affects lymphocytes and potentially results in dysfunction even after clinical recovery.
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