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目的 探讨尿α1-微球蛋白和尿微量白蛋白对糖尿病肾病早期的诊断意义。方法 利用速率免疫 散射比浊法对108例不同程度的糖尿病患者及60例健康对照者尿蛋白定性、尿α1-微球蛋白(α1-MG)、尿微量 白蛋白(MA)和尿转铁蛋白(TRF)进行检测分析。结果 糖尿病组尿α1-微球蛋白和尿微量白蛋白的测定结果明 显高于健康对照组(P<0.01)。结论 联合检测尿α1-微球蛋白和尿微量白蛋白有助于了解糖尿病病人早期肾 损伤的情况,对糖尿病肾病的早期诊断有重要意义。
Objective To investigate the early diagnostic significance of urinary α1-microglobulin and urinary microalbuminuria in diabetic nephropathy. Methods The urinary protein, urinary α1-microglobulin (α1-MG), urinary microalbumin (MA) and urine transferrin in 108 patients with diabetes and 60 healthy controls were determined by the method of speed immune nephelometry. (TRF) for testing and analysis. Results The urinary α1-microglobulin and urine microalbuminuria in diabetic patients were significantly higher than those in healthy controls (P <0.01). Conclusions The combined detection of urinary α1-microglobulin and urinary microalbumin helps to understand the situation of early renal injury in diabetic patients and is of great significance in the early diagnosis of diabetic nephropathy.