【摘 要】
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Dear Editor,rnYes-associated protein(YAP)is a transcriptional coactivator that plays an essential role in promoting cell proliferation,development and stem cell fate.1 Aberrant YAP activation is prevalent in diverse types of human solid cancers.2 In mamma
【机 构】
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Interdisciplinary Research Center on Biology and Chemistry,Shanghai Institute of Organic Chemistry,C
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Dear Editor,rnYes-associated protein(YAP)is a transcriptional coactivator that plays an essential role in promoting cell proliferation,development and stem cell fate.1 Aberrant YAP activation is prevalent in diverse types of human solid cancers.2 In mammals,a kinase cascade including MST1/2 and LATS1/2 phosphorylates YAP to prevent its nuclear translocation and subsequent interaction with the TEA domain transcription factors TEAD1-4 in the canonical Hippo pathway.Previous studies have intensively emphasized the upstream signals from the Hippo kinase cascade that regulates YAP;1,3 however,the epigenetic regulatory mechanism of YAP transcriptional activity is far less understood.Given the importance of YAP in cancer progression and limited druggability of YAP/TEAD as transcriptional factors,identification of YAP proximal regulators is of great importance to develop new therapeutic strategies for the treatment of cancer.
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