论文部分内容阅读
目的:探讨不同氧浓度复苏对创伤性轴索损伤(TAI)合并低氧血症性二次脑损伤(SBI)大鼠模型的丙二醛(MDA)和超氧化物歧化酶(SOD)含量的影响。方法:48只SD大鼠,随机分为假手术组(A组)8只、损伤合并低氧血症组(B组)8只及损伤合并低氧后复苏组(C组)32只,根据不同氧浓度C组又分为21%、50%、75%、100%4个亚组。应用自制的TAI致伤装置制备模型,大鼠致伤后给予10%浓度氧吸入30 min制成低氧血症性SBI模型,之后给予不同氧浓度混合气体1 h,检测大鼠不同氧浓度通气复苏后24 h、1周时MDA、SOD变化情况。结果:与A组相比,B组及C组24 h时MDA含量明显升高,1周后恢复至正常水平;C组与B组比较,21%、50%亚组的MDA下降,差异有统计学意义(P<0.05);C组随氧浓度升高MDA值逐渐升高。B组及C组24 h时SOD含量明显下降,与A组比较差异有统计学意义(P<0.05),1周时仍低于正常水平;C组与B组比较,给予21%氧复苏时SOD值明显升高(P<0.05),给予50%、75%氧复苏时SOD差异无统计学意义(P>0.05),给予100%氧复苏时SOD值明显降低(P<0.05);C组随氧浓度升高SOD值逐渐降低。结论:适当的给氧治疗能改善和纠正脑组织缺氧,但随着给氧浓度的增加,MDA不断增高,SOD则不断降低。
Objective: To investigate the changes of malondialdehyde (MDA) and superoxide dismutase (SOD) in rats with traumatic axonal injury (TAI) and hypoxemic secondary brain injury (SBI) influences. Methods: Forty eight Sprague-Dawley rats were randomly divided into sham operation group (A group), n = 8, injury and hypoxemia group (B group), and injury and hypoxemia recovery group (C group) Different oxygen concentration C group is divided into 21%, 50%, 75%, 100% 4 subgroups. The model of TAI injury device was made by ourselves. After the rats were injured, 10% oxygen inhalation was given for 30 min to make hypoxemic SBI model. After that, the mixed gas of different oxygen concentration was given for 1 hour. Changes of MDA and SOD at 24 h and 1 week after resuscitation. Results: Compared with group A, the content of MDA in group B and group C increased significantly at 24 h, and returned to normal level after one week. The MDA in group C was lower than that in group B at 21% and 50% Statistical significance (P <0.05); C group with the increase of oxygen concentration MDA value gradually increased. The content of SOD in group B and group C decreased significantly at 24 h, which was significantly lower than that in group A (P <0.05), and still lower than normal level at 1 week. In group C and group B, 21% oxygen resuscitation (P <0.05). SOD at 50% and 75% Oxygen resuscitation had no significant difference (P> 0.05), SOD at 100% oxygen resuscitation decreased significantly (P <0.05) With the increase of oxygen concentration, the SOD value decreased gradually. Conclusion: Appropriate oxygen therapy can improve and correct hypoxia in brain tissue. However, with the increase of oxygen concentration, MDA is continuously increased and SOD is decreased continuously.