人-人杂交瘤制备人的单克隆抗体虽然取得了一些成功,但到目前为止,仍缺乏理想的人的骨髓瘤细胞株,并普遍存在产生特异性抗体的阳性率低、很不稳定等问题.本文作者建立了一个人骨髓瘤类似物(analog)-LSM2.7.该细胞株是用人骨髓瘤细胞突变株LSM1.1与未免疫的正常人外周血单个核细胞融合后产生的,它不分泌人的 Human-human hybridoma preparations of human monoclonal antibodies have achieved some success, but so far, the ideal human myeloma cell lines are still lacking, and there is a widespread problem that the positive rate of producing specific antibodies is low and very unstable The authors of this article established a human myeloma analogue, LSM2.7, which was generated after fusion with unimmunized normal human peripheral blood mononuclear cells using the human myeloma cell line LSM1.1 Secretive