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作者通过酶标抗体法测定10年前石腊包埋肝组织的 HBsAg,随访评价慢性活动性肝炎的皮质醇或免疫抑制治疗的效果。57例慢性肝炎,其中38例应用皮质醇或免疫抑制剂,对照组19例不应用皮质醇。治疗组分为皮质醇组16例,其中肝组织 HBsAg阳性4例,硫唑嘌呤或6MP 组13例,其中肝组织HBsAg 阳性3例;皮质醇和硫唑嘌呤用或不用6MP5例,其中肝组织 HBsAg 阳性5例;对照组15例中肝组织 HBsAg 阳性4例。皮质醇基本用强的松龙,开始1～2周内应用20～30mg/d,以后连续每周应用20mg/d 共4天,停药3天,平均应用27.9±15.7周。硫唑嘌呤开始应用50～100mg/d 1～2周,6MP 开始应用50mg/d 1～2周,以后维持量每周应用4天停药3天。依实验室和临床肝
The authors used enzyme-linked immunosorbent assay to determine HBsAg in paraffin-embeded liver tissue 10 years ago and evaluated the effect of cortisol or immunosuppressive therapy on chronic active hepatitis. 57 cases of chronic hepatitis, of which 38 cases of cortisol or immunosuppressive agents, the control group of 19 patients without cortisol. The treatment group consisted of 16 cases of cortisol group, including 4 cases of HBsAg positive in liver tissue, 13 cases of azathioprine or 6MP group, 3 cases of HBsAg positive in liver tissue, 5 cases of cortisol and azathioprine with or without 6MP, including liver tissue HBsAg Positive in 5 cases; control group of 15 cases of liver tissue HBsAg positive in 4 cases. Cortisol with prednisolone, the first 1 to 2 weeks of application of 20 ~ 30mg / d, after a continuous weekly application of 20mg / d for 4 days, withdrawal of 3 days, the average application of 27.9 ± 15.7 weeks. Azathioprine began to apply 50 ~ 100mg / d for 1 ~ 2 weeks, 6MP began to apply 50mg / d for 1 ~ 2 weeks, after the maintenance dose weekly for 4 days for 3 days. According to the laboratory and clinical liver