近年来,微量元素(如铜、锌、硒、铁)和正常免疫功能之间的复杂关系,越来越引起人们的广泛重视。大量研究揭示了铜缺乏会引起细胞功能的改变,尤其影响细胞的免疫功能。表现在:①T细胞,特别是T辅助细胞(T_H)的绝对数和相对百分数减少;②脾淋巴细胞对T细胞和B细胞有丝分裂原的应答显著降低;③抗体生成细胞的反应减少;④ In recent years, the complex relationship between trace elements (such as copper, zinc, selenium, iron) and normal immune function has drawn more and more attention. Numerous studies have revealed that copper deficiency can cause changes in cell function, especially affecting cellular immune function. The results showed that: (1) the absolute numbers and the relative percentages of T cells, especially T helper cells (T_H) were decreased; (2) the response of splenic lymphocytes to mitosis of T cells and B cells was significantly reduced; (3) the reaction of antibody-producing cells was reduced;