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应用某镍冶炼厂作业环境中存在的几种镍剂,给三种小鼠右腋皮下注射,每鼠5mg,观察62周。仅见镍精砂(主要含Ni_3S_2)有局部诱癌作用。其病理组织学表现以纤维肉瘤为主,亦见2例横纹肌肉瘤,大多数肿瘤分化差,有浸润性,个别发生肝、肺转移。此结果提示该厂环境中存在的镍精砂可能对人类也具有致癌危险性,在考虑劳保措施和职业癌的防治中应引起足够重视。
Application of several nickel agents present in the operating environment of a nickel smelter. Three mice were injected subcutaneously in the right iliac crest with 5 mg per mouse for 62 weeks. Only the nickel concentrate sand (mainly containing Ni_3S_2) had a local carcinogenic effect. Histopathological histology was mainly fibrosarcoma, also seen in 2 cases of rhabdomyosarcoma, most of the tumors were poorly differentiated and infiltrating, and liver and lung metastases occurred individually. This result suggests that the nickel concentrate sand present in the plant environment may have a carcinogenic risk to humans, and should be given sufficient attention in considering the labor insurance measures and the prevention and treatment of occupational cancer.