The potentially bioactive 2-aryl-thiazolo[4,5-b]pyridines were synthesized via palladium-catalyzed desulfitative cross-coupling reaction between multisubstituted thiazolo[4,5-b]pyridine thioethers and boronic acids. Yields of [2_TD$IF]48%–94% were obtained with copper(I) thiophene-2-carboxylate in the system. The potentially bioactive 2-aryl-thiazolo [4,5-b] pyridines were synthesized via palladium-catalyzed desulfitative cross-coupling reaction between multisubstituted thiazolo [4,5-b] pyridine thioethers and boronic acids. Yields of [2_TD $ IF] 48% -94% were obtained with copper (I) thiophene-2-carboxylate in the system.