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乳腺康口服液是由莪术、丹参等中药组方,具有活血化瘀、理气通滞之功效,用于乳腺小叶增生,以发挥消散乳房肿块、解除肿胀的作用。该制剂为乳腺康注射剂的改造剂型。为了解其毒性大小,以保证临床应用的安全,我们进行了该制剂的急性毒性试验。由于受浓度和体积的限制,实验中未测出该制剂的半数致死量,而测出其小白鼠灌胃、腹腔注射、静脉注射的最大的受量分别为(相当生药量)200g/kg、133g/kg、67g/kg。
The breast milk oral liquid is composed of Curcuma and Salvia miltiorrhiza Bunge. It has the effect of promoting blood circulation and removing phlegm, and regulating qi and stagnating qi. It is used for the proliferation of breast lobule to play a role of dissipating breast mass and relieving swelling. The preparation is a modified form of maikang kang injection. To understand the size of its toxicity and to ensure the safety of clinical applications, we conducted an acute toxicity test of the preparation. Due to the limitation of concentration and volume, the half-lethal dose of this preparation was not measured in the experiment, and the maximum doses measured by the mice in the gavage, intraperitoneal injection, and intravenous injection were respectively (a considerable amount of crude drug) 200 g/kg, 133g/kg, 67g/kg.