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伐地昔布的严重皮肤不良反应伐地昔布(Valdecoxib)是选择性环氧合酶-2抑制药,其适应证为类风湿性关节炎及骨关节炎,可缓解其疼痛。其严重的皮肤不良反应包括多形性红斑,斯-约(Stevens-Johnson) 综合征及中毒性表皮坏死溶解症。加拿大产品专题研究报告提到下列信息:①用伐地昔布后一旦出现皮疹或其他过敏症状应立即停药;②对磺胺类药物过敏者禁用本品;③服用ASA或其他NSAIDs发生
Valdecoxib is a Selective Cyclooxygenase-2 Inhibitor with indications of rheumatoid arthritis and osteoarthritis, which can relieve pain. Serious skin adverse reactions include erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis. Canadian product research report referred to the following information: ① once after the use of valdecoxib rash or other allergy symptoms should be discontinued immediately; ② allergic to sulfa drugs banned this product; ③ taking ASA or other NSAIDs occurred