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Johuson和Walker首先发现青霉素心室内给药可引起惊厥,并在猫和猴中实验发现,青霉素置于大脑皮层表面,可产生对侧肌阵挛性肌痉挛,若用于已被麻醉的动物皮层,则变成标准新皮层灶性癫痫模型。其致癫痫作用可能为青霉素的化学结构与γ-氨基丁酸
Johuson and Walker first found penicillin intraventricular administration can cause convulsions and experiments in cats and monkeys found that penicillin placed on the surface of the cerebral cortex can produce contralateral myoclonus muscle spasm, if used in anesthetized animal cortex , It becomes a standard neocortex focal epilepsy model. Its epileptic effect may be the chemical structure of penicillin and γ-aminobutyric acid