论文部分内容阅读
目的:探讨分析尿微量蛋白在2型糖尿病肾病诊治中的作用。方法:选择2型糖尿病患者68例作为观察组,选择同期65名健康者为对照组。采用散射比浊法测定两组尿蛋白、转铁蛋白(TRF)、β2-微球蛋白(β2-MG)、微量清蛋白(mALB)、尿a1-微球蛋白(al-MG)水平。结果:观察组尿蛋白、尿微量蛋白阳性率分别为23.52%和57.35%,与对照组比较差异有统计学意义(P<0.05);mALB、β2-MG、a1-MG及TRF水平,尿蛋白阳性组高于阴性组,尿蛋白阴性组高于健康组,差异均有统计学意义(P<0.05);TRF、alMG、mAlb及β2-MG水平,5年以上病程患者显著高于5年以下病程患者,5年以下病程患者高于健康组,差异均有统计学意义(P均<0.05)。结论:4种尿微量蛋白联合检测,可以为早期2型糖尿病肾病的诊断、监测提供可靠依据。
Objective: To investigate the role of urine microalbumin in the diagnosis and treatment of type 2 diabetic nephropathy. Methods: Sixty-eight patients with type 2 diabetes mellitus were selected as the observation group and 65 healthy controls were selected as the control group. Urinary protein, transferrin (TRF), β2-microglobulin (β2-MG), myalbumin (a) and urinary a1-microglobulin (al-MG) were measured by nephelometry. Results: The positive rates of urinary protein and urinary microalbumin in the observation group were 23.52% and 57.35% respectively, which were significantly different from those in the control group (P <0.05). The levels of mALB, β2-MG, a1-MG and TRF, The positive rates of TRF, alMG, mAlb and β2-MG in patients with more than 5 years of disease were significantly higher than those of patients with less than 5 years (P <0.05) Patients with duration of disease, patients with disease less than 5 years were higher than those with health status, the differences were statistically significant (all P <0.05). Conclusion: The combined detection of four kinds of urine microalbumin can provide a reliable basis for the diagnosis and monitoring of early type 2 diabetic nephropathy.