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因为一些汉方方剂具有免疫调节和抗炎作用,故用它们替代糖皮质激素,长期服用以治疗慢性炎症。虽然这些方剂具有很好的临床疗效,但其药理作用机制仍不甚清楚。本文研究了白虎加人参汤对小鼠双相皮肤反应和接触性皮炎的作用及其作用机理。 材料与方法:①药物:白虎加人参汤(TJ-34)是一种水提取液,在抗原诱导之前1h口服;泼尼松龙在每次皮肤试验前2h腹腔注射;氨来呫诺为阳性对照药。②IgE介导的皮肤反应:试验前24h,Balb/c小鼠通过静脉注射抗二硝基苯酚单克隆IgE
Because some Chinese herbs have immunomodulatory and anti-inflammatory effects, they are used instead of glucocorticoids and long-term use to treat chronic inflammation. Although these prescriptions have good clinical efficacy, their pharmacological mechanism is still not clear. This paper studied the effect of Baihujiarenshen decoction on biphasic skin reaction and contact dermatitis in mice and its mechanism of action. MATERIALS AND METHODS: 1 Drug: Baihujia ginseng decoction (TJ-34) is an aqueous extract that was given 1 h before antigen induction; prednisolone was intraperitoneally injected 2 hours before each skin test; azonex was positive. Control medicine. 2IgE-mediated skin reactions: Balb/c mice were intravenously injected with anti-dinitrophenol monoclonal IgE 24 h before the test