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肿瘤的发生.发展,转移都依赖于血管的供应营养,肿瘤区血管的生长是正常组织的50～200倍,是什么因子促使肿瘤区血管的生长?已知的正调因子有十余种之多,主要为:VEGF,PDGF,FGF及TGF-β.本工作用免疫组化法检测了这四种因子在多种组织的表达,结果发现:一、B-FGF,TGF-β,PDGF,VEGF在胃癌,大肠癌,肝癌细胞内均有不同程度的表达,并分泌至细胞外.而正常消化道组织不表达,二、除在
The occurrence, development, and metastasis of tumors depend on the supply of blood vessels, and the growth of blood vessels in the tumor area is 50 to 200 times that of normal tissues. What factors contribute to the growth of blood vessels in the tumor area? There are more than 10 kinds of known up-regulation factors. Most of them are: VEGF, PDGF, FGF and TGF-β. The present work detected the expression of these four factors in various tissues by immunohistochemistry and found that: 1. B-FGF, TGF-β, PDGF, VEGF is expressed in various degrees in gastric cancer, colorectal cancer, and hepatocellular carcinoma cells, and is secreted extracellularly. Normal gastrointestinal tissues do not express it. Second, in addition to