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大骨节病的主要变化从X线及病理解剖检查的结果来看主要集中在软骨,包括骨骺和关节软骨。肉眼观察即可发现关节软骨有坏死和溃瘍形成;显微镜检查可是骺板软骨细胞坏死,间质染色不良及早期化骨等现象。可见,软骨的变化主要是营养不良性的。我们知道,软骨是结缔组织生理系统的组成部分。既然大骨节病的病理变化主要集中于软骨,检查大骨节病患者结缔组织生理系统的机能状态当具有一定的意义。到目前为止,我们对大骨节病的病因学和发病学都了解得很少。检查大骨节病患者结缔组织生理系统的机能状态,或许对探索大骨节病的发病学有所帮助。
The main changes in Kashin-Beck disease mainly from cartilage, including osteophytes and articular cartilage. Visual observation can be found in the articular cartilage with necrosis and ulceration; microscopic examination may be necrotic chondrocytes, poor interstitial staining, and early bone formation. It can be seen that the cartilage changes are mainly malnutrition. We know that cartilage is an integral part of the physiological system of connective tissue. Since the pathological changes of Kaschin-Beck disease mainly focus on cartilage, it is of certain significance to examine the functional status of the connective tissue physiological system in patients with Kaschin-Beck disease. So far, we know very little about the etiology and pathogenesis of Kashin-Beck disease. Examining the functional status of the connective tissue physiological system in patients with Kaschin-Beck disease may be helpful in exploring the pathogenesis of Kaschin-Beck disease.