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目的:观察参附注射液对正常心肌细胞膜上L-型钙通道的影响。方法:在急性酶分离的单个心肌细胞上,利用膜片钳单通道记录技术观察参附注射液对正常心肌细胞膜上L-型钙通道的影响。结果:0.3、0.6、1.2g/kg参附注射液可浓度依赖性地增加L-型钙通道的平均开放概率,由0.008±0.0007分别增加至0.014±0.0009、0.016±0.0014及0.018±0.0011。结论:参附注射液可增加正常心肌细胞膜L-型钙通道的开放,促进钙离子的内流,达到增加心肌收缩力的作用。
Objective: To observe the effect of Shenfu injection on L-type calcium channel in normal myocardial cell membrane. METHODS: The effect of Shenfu Injection on the L-type calcium channel in normal myocardial cell membrane was observed by single-channel recording technique of acute enzymatic separation. RESULTS: 0.3, 0.6, 1.2 g/kg Shenfu injection could increase the average open probability of L-type calcium channels in a concentration-dependent manner, which increased from 0.008±0.0007 to 0.014±0.0009, 0.016±0.0014, and 0.018±0.0011, respectively. Conclusion: Shenfu injection can increase the opening of L-type calcium channels in normal myocardial cell membrane, promote the influx of calcium ions, and increase the myocardial contractility.