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本文应用小鼠腹水型肝癌淋巴道转移模型(H_(22)/F23),初步探讨了瘤苗主动免疫对H_(22)/F23的免疫预防效应以及对肿瘤生长和淋巴道转移的治疗作用。CFW系小鼠经β-榄香烯和丝裂霉素C处理的H_(22)/F23瘤细胞腹腔免疫三次,末次免疫后两周分别用H_(22)/F23和H_(22)交叉进行攻击。结果表明:β-榄香烯及MMC瘤苗均能诱导不同程度的免疫保护效应,后者效果更为显著。两种方法处理的H_(22)/F23瘤苗免疫对H_(22)/F23攻击的保护效应显著低于对H_(22)的保护效应,提示高淋巴道转移株H_(22)/F23细胞的免疫原性较低,推测这可能与其转移能力的增高有一定关系。用MMC处理的瘤苗细胞和非特异性免疫制剂(CP)对带瘤小鼠进行免疫治疗的结果证示:免疫治疗不仅明显抑制肿瘤生长,并可显著降低肿瘤淋巴道转移的发生率。
In this study, the mouse model of lymphatic metastasis of ascites type liver cancer (H_(22)/F23) was used to investigate the effect of active immunization of tumor vaccines on H_(22)/F23 immunopreventive effect and the therapeutic effect on tumor growth and lymphatic metastasis. The H22/F23 tumor cells treated with β-elemene and mitomycin C were immunized intraperitoneally three times in CFW mice, and crossed with H22/F23 and H22 in the two weeks after the last immunization. attack. The results showed that both β-elemene and MMC vaccines could induce different degrees of immunoprotective effects, with the latter being more effective. The protective effect of H_(22)/F23 vaccine vaccine against H_(22)/F23 challenge was significantly lower than that of H_(22) treatment by two methods, suggesting that H_(22)/F23 cells were highly metastatic The immunogenicity is low, presumably this may have a certain relationship with the increase in metastatic capacity. The results of immunotherapy of tumor-bearing mice with MMC-treated neoplastic cells and non-specific immune preparations (CP) showed that immunotherapy not only significantly inhibited tumor growth, but also significantly reduced the incidence of lymphatic metastasis.