论文部分内容阅读
用Forgarty导管对35只大鼠行主动脉内皮细胞剥脱。在1、5、10、15d时,主动脉平滑肌细胞增生和内膜增厚以及c-sis基因表达随时间的延长而增加。内皮剥脱20d时,内膜增厚的程度与15d时相比变化不大,但c-sis基因表达较15d的低。结果提示,c-sis可能在平滑细胞增殖和内膜增厚过程中起重要作用。
Thirty-five rats were stripped of aortic endothelial cells with Forgarty catheters. At 1, 5, 10 and 15 days, aortic smooth muscle cell proliferation and intimal thickening and c-sis gene expression increased with time. Endothelium exfoliated 20d, the extent of intimal thickening and 15d compared to little change, but c-sis gene expression was lower than 15d. The results suggest that c-sis may play an important role in the process of smooth cell proliferation and intimal thickening.