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长期以来,临床医生都把血清白蛋白水平视为肝功能状态的可信赖的指标。近十年多来对白蛋白的代谢有了比较全面和深入的了解,认识到肝脏合成白蛋白的储力相当大,所有肝细胞都能合成白蛋白,而正常时只有15～30％的肝细胞在合成白蛋白。即使肝脏合成白蛋白功能受到抑制,血浆白蛋白浓度趋向下降时,血管外白蛋白也可向血管内转运,补充血浆白蛋白的不足,同时降解也可减慢,补偿合成的不足。只有这些代偿功能不足或遭到破坏时,血清白蛋白浓度才开始下降。白蛋白的半寿期
For a long time, clinicians regarded serum albumin as a reliable indicator of liver function. Over the past decade and more on the metabolism of albumin has a more comprehensive and in-depth understanding of the liver storage of synthetic albumin quite large, all the liver cells can synthesize albumin, and normal only 15 to 30% of the liver cells In the synthesis of albumin. Even if the hepatic synthetic albumin function is inhibited, the serum albumin concentration tends to decline, extravascular albumin can also be transported to the blood vessels, complement the lack of plasma albumin, while degradation can also slow down to compensate for the lack of synthesis. Serum albumin concentrations begin to decline only if these compensatory functions are inadequate or disrupted. Albumin half-life