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本文对100例消化性溃疡患者在内镜直视下用活检钳及细胞刷彻底清除溃疡面坏死苔后通过局部注射针将灭滴灵注入溃疡底及边缘的粘膜内。1周后溃疡愈合率达64%,4周内愈合率达92%,显著高于同期服甲氰咪胍组和清创注射生理盐水组(P<0.005)。复发率仅为3%。实验研究表明,灭滴灵的抗溃疡作用为:保护胃粘膜,抑制和杀灭幽门弯曲杆菌.
In this paper, 100 cases of patients with peptic ulcer endoscopic biopsy with biopsy forceps and brush completely remove the necrotic ulcer after the coating of local injection needle metronidazole into the mucosa at the bottom of the ulcer and the edge. After 1 week, the healing rate of ulcer was 64% and the healing rate was 92% within 4 weeks, which was significantly higher than that of cimetidine group and debridement injection saline group (P <0.005). The recurrence rate was only 3%. Experimental studies have shown that metronidazole anti-ulcer effect: to protect the gastric mucosa, inhibit and kill Campylobacter pylori.