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目的:考察磷霉素钠与加替沙星氯化钠注射液配伍变化,为临床合理用药提供参考依据。方法:在室温条件下观察及测定配伍液8h内的pH及外观变化,并检测配伍液中加替沙星的紫外光谱图和含量变化。结果:两药配伍后8h内配伍液的pH及外观无明显变化,而配伍液中加替沙星的紫外图谱和含量均有明显变化。结论:磷霉素钠不宜和加替沙星氯化钠注射液配伍使用。
Objective: To investigate the compatibility of fosfomycin sodium and gatifloxacin sodium chloride injection, to provide a reference for clinical rational drug use. Methods: The pH and appearance changes of the compatibility solution were observed and measured at room temperature. The ultraviolet spectrum and content of Gatifloxacin in the compatibility solution were also tested. Results: There was no significant change in the pH and appearance of the compatibility solution within 8 hours after the compatibility of the two drugs. However, the UV spectrum and content of gatifloxacin in the compatibility solution were significantly changed. Conclusion: Fosfomycin sodium should not be used with Gatifloxacin sodium chloride injection.